Cell Biology and Anatomy

Research includes using a muscle cell culture model in which we can observe the aggregation of known synaptic molecules in response to neurons or active factors such as neural agrin. There appear to be 2 basic pathways which regulate the aggregation of synaptic molecules: one involves signal transduction and tyrosine phosphorylation while the other may involve structural interactions on the extracellular surface. When observed in detail, the aggregation is quite dynamic in surprising ways that we hope will promote a better understanding of the underlying processes & nbsp; Future research will hope to answer the question of how one synapse gets larger at the expense of the other.

Milholland RB Gordon H. Jul 2007. A role for acetylcholine receptors in their own aggregation on muscle cells. Dev Neurobiol, 67:999-1008

Milholland RB Dulla C Gordon H. Jul 2007. L-type calcium channels mediate acetylcholine receptor aggregation on cultured muscle. Dev Neurobiol, 67:987-98

St John PA, Gordon H. Nov 2001. Agonists cause endocytosis of nicotinic acetylcholine receptors on cultured myotubes. J Neurobiol, 49:212-23

Grow WA, Gordon H. Feb 2000. Sialic acid inhibits agrin signaling in C2 myotubes. Cell Tissue Res, 299:273-9

Grow WA, Gordon H. Feb 2000. Acetylcholine receptors are required for postsynaptic aggregation driven by the agrin signalling pathway. Eur J Neurosci, 12:467-72

Grow WA, Ferns M, Gordon H. Sep 1999. Agrin-independent activation of the agrin signal transduction pathway. J Neurobiol, 40:356-65

Grow WA, Ferns M, Gordon H. Jan 1999. A mechanism for acetylcholine receptor clustering distinct from agrin signaling. Dev Neurosci, 21:436-43

Graf RA, Kater SB, Gordon H. Jan 1999. Prolonged cytosolic calcium elevations in growth cones contacting muscle. Dev Neurosci, 21:409-16

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