Cell Biology and Anatomy

The Questions we care about:
We are interested in understanding how nuclear architecture, chromosome morphology and chromatin structure are modified in response to developmental cues.  We are also interested in elucidating the molecular mechanisms through which these modifications function and effect specialized cellular processes.  The types of processes that we study are:
(1) the formation of chromosome territories and polytene chromosomes.
(2) chromosome condensation.
(3) homology dependent pairing of chromosomes in meiosis and somatic interphase cells.
(4) pairing sensitive gene expression, e.g. transvection.
(5) chromosome and chromatin structure and epigenetic gene regulation.
(6) heterochromatin satellite DNA and genome evolution.

Our favorite model:
We primarily work with Drosophila as a model system because it s amenable to powerful genetic/genomic analysis and cell biological techniques.  In addition, the rich history and knowledge derived from previous studies of Drosophila chromosomes, combined with modern genetic/genomic and imaging technologies affords us the ability to dissect and visualize a variety of dynamic chromosome structures. 

Our goal:
Our goal is to understand the basic rules of how the structure of chromosomes and chromatin are regulated in the Drosophila system.  As we better understand how changes in these structures effect their function it will lead to insights that are fundamental to many critical cellular processes, such as chromosome segregation and genome stability, gene expression and epigenetic gene regulation.

Ahlander J, Bosco G. Apr 2009. Sqd interacts with the Drosophila retinoblastoma tumor suppressor Rbf. Biochem Biophys Res Commun,2009 Apr 10;

Epstein AM, Bauer CR, Ho A, Bosco G, Zarnescu DC. Mar 2009. Drosophila fragile X protein controls cellular proliferation by regulating cbl levels in the ovary. Dev Biol,2009 Mar 21;

Bosco G. Feb 2009. When segregation hangs by a thread. PLoS Genet, 5:e1000371

Hartl TA, Smith HF, Bosco G.. Dec 2008. Chromosome alignment and transvection are antagonized by condensin II.. Science, 322(5906):1384-7

Bauer CR, Epstein AM, Sweeney SJ, Zarnescu DC, Bosco G. Nov 2008. Genetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks. BMC Syst Biol, 2:101

Hartl TA, Sweeney SJ, Knepler PJ, Bosco G. Oct 2008. Condensin II Resolves Chromosomal Associations to Enable Anaphase I Segregation in Drosophila Male Meiosis. PLoS Genet, 4:e1000228

Ahlander J, Chen XB, Bosco G.. Jul 2008. The N-Terminal Domain of the Drosophila Retinoblastoma Protein Rbf1 Interacts with ORC and Associates with Chromatin in an E2F Independent Manner.. PLoS ONE, 3:e2831

Sweeney SJ, Campbell P, Bosco G. Feb 2008. Drosophila sticky/citron kinase is a regulator of cell cycle progression, genetically interacts with Argonaute 1 and modulates epigenetic gene silencing. Genetics, 178:1311-25

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